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[27] [75] Covalent regulation in the liver The hepatic isoenzyme , but not the muscle isoenzyme, is also regulated by phosphorylation through: primarily protein kinase A (PKA), activated by glucagon (or epinephrine via -adrenergic receptors)

112 Moreover, YAP, a crucial transcriptional co-activator, also undergoes lactylation and enhances its nuclear localization and subsequent interaction with TEAD, thereby collectively promoting the expression of Hippo pathway target genes

Unlike the first generation GLP-1 medications like semaglutide and liraglutide, tirzepatide works on a second hormone called GIP which increases its efficacy in many patients

10.1038/nature10146 67 LoY